Tuesday, 11th February The 45th Lorne Conference on Protein Structure and Function 2020
Registration Opens
8:00AM - 1:30PM
Tuesday, 11th February
Session 7 - Cryo-EM Joint Session with Satellite
8:30AM - 10:30AM
Tuesday, 11th February
Chairs: Michael Landsberg & James Whisstock
- Replenishing the ends: Structural mechanism of human telomerase - Kelly Thi Hoang Duong Nguyen
- The structure of MPEG1: A case study for difficult, heterogeneous samples in cryoEM - Charles Bayly-Jones
- Solving the First Novel Protein Structure by Micro-Crystal Electron Diffraction - Mathieu Coinçon
- Biological mechanisms elucidated by cryo-EM - Stefan Raunser
Morning Tea
10:30AM - 11:00AM
Tuesday, 11th February
Session 8 - Split session with Workshop – Lightning Talks
11:00AM - 1:00PM
Tuesday, 11th February
Auditorium
Chairs: James Murphy & Helen Walden
- Structural plasticity between homo and heterodimeric IRF4-DNA Interactions - Srinivasan sundararaj
- Convergent evolution reshape the structure and function of a histone-modifying complex - Qi Zhang
- Molecular Mechanisms governing αβ T-cell receptor autoreactivity towards CD1b - Adam Shahine
- Biophysical characterisation of Class F G protein-coupled receptor activation - Mark Agostino
- Copper chelation and oxygenase activity at the histidine brace - Katja s Johansen
- Leveraging structures of substrate-binding proteins (SBPs) to redefine nutrient acquisition by marine cyanobacteria - Bridget C Mabbutt
- A compound that enhances HDR CRISPR for the generation of transgenic mice - Stephen Headey
- Reagentless biosensors for 1-step detection of protein biomarkers - Simon R Corrie
- Var2Prot: A new tool to unravel the 3D structural effect of genetic variants - Sergio Ruiz-Carmona
Cryo-EM Workshop B
11:00AM - 1:00PM
Tuesday, 11th February
Horizons Room
Chairs: Isabelle Rouiller &
- ISOLDE: bringing macromolecular model building to life - Tristan Croll
- TIR-domain-assembly formation in Toll-like receptor signaling pathways - Jeffrey D Nanson
- For when it’s complicated: How an integrative structural approach sheds light on native apolipoprotein-D structure - Claudia S Kielkopf
- Structural insights into allostery and bias at the adenosine A1 receptor. - Christopher Draper-Joyce
- A chimeric viral platform provides a unified route to structure determination of pathogenic flaviviruses by cryo-EM - Joshua M Hardy
- The cooperative assembly and disassembly of NanR, a GntR-type transcriptional regulator of sialic acid catabolism in Escherichia coli. - Chris R. Horne
- Real-time analysis to speed structure solution - Susan Lea
Lunch
1:00PM - 2:00PM
Tuesday, 11th February
Waters Trade Workshop
1:00PM - 2:00PM
Tuesday, 11th February
Auditorium
Sponsored by:
Free Time
2:00PM - 4:00PM
Tuesday, 11th February
Cryo-EM Workshop C
2:00PM - 4:00PM
Tuesday, 11th February
Horizons Room
Chairs: Wim Voorhout & James Bouwer
- SIMPLE 3.0. Stream single-particle analysis for informing and validating cryo-EM data acquisition in real time - Dominika Elmlund
- chameleon: next generation sample preparation for cryo-EM - Paul Thaw
- Towards high-throughput in-situ structural biology - Alex de Marco
- Structure of MyD88 TIR domain filaments revealed by microcrystal electron diffraction - Max T.B. Clabbers
Registration re-opens
4:00PM - 6:00PM
Tuesday, 11th February
Poster session C - including refreshments
4:00PM - 6:00PM
Tuesday, 11th February
- Understanding How cancer Mutations Disrupt Non-Homologous DNA-Repair. - Raghad Al Jarf
- Structural and functional investigation of the arsenate periplasmic binding protein ArrX from Chrysiogenes arsenatis - Nilakhi Poddar
- Structural studies of a dodecameric Ketol-acid reductoisomerase. - Shan Zheng
- The interaction of apoA-I with submicellar lipids and lipid-like molecules - Phoebe Tou
- Online databases complement wet lab approaches to understanding peptide GPCR function - Alice R Whitehead
- Developing novel frontotemporal dementia therapeutics to rescue TDP-43 mistranslocation and facilitate clearance - Hei Wun Alison Cheng
- Investigating the role of the calcium-sensing receptor in airway contraction using mouse precision cut lung slices - Jiayin JD Diao
- Regulating self-association of the stress granule RNA-binding protein TIA-1 - Danella West
- Structural and biophysical details of hSSB1 oligomerisation in response to oxidative DNA damage - Serene El-Kamand
- Implementation of protein biosensor on the personalized health care for diabetes. - Uthayasuriya Sundaramoorthy
- Understanding the effect of naturally occurring human MLKL polymorphisms on necroptosis and disease - Sarah E Garnish
- Using gidB protein structure to identify novel streptomycin resistance mutations in Mycobacterium tuberculosis - Noa Levi
- Studies on important enzymes of Multi Drug Resistant Staphylococcus aureus (hVISA Mu50). - Faryal ashraf
- Identification and structural prediction of the native protease of a newly isolated yeast specie from spoilt orange - Okojie Eseoghene Lorrine
- Structural characterisation of a Schistosoma japonicum asparaginyl tRNA-synthetase - Yoshimi Peck
- The dynamics of central channel nucleoporin complexes and architectural conservation across species - Sangeeta Niranjan
- Structural and functional characterization of MlaD from Acinetobacter baumannii - Jing Zhang
- CHARACTERISING NOVEL B1 METALLO-β-LACTAMASES (MBLs) - Sasiprapa Miss Prombhul
- Elucidating the Zn(II)-binding mechanism of Streptococcus pneumoniae AdcAII - Marina Zupan
- Unravelling the molecular contributions to collagen higher order structure - Danielle R Visser
- Macrocyclic peptides as novel chemical tools to modulate the Retromer endosomal trafficking complex - Qian Guo
- Unravelling the active site of small heat-shock proteins using NMR - Emily E. Selig
- Spatially mapping brain metabolism in a mouse model of Huntington’s disease - Farheen FF Farzana
- Structural insights into Type II ABC Tc cell recognition - Joseph K Box
- Structural and functional characterization of insect defensins - Zhanzhao Yang
- Defining conserved nature of apoptotic Bcl-2 family protiens in the most primitive and evolutionary ancient animal on earth, Trichoplax adhaerens - Jaison J D Sa
- Recombinant expression of Insulin-like growth factor-ii analogues for investigation of receptor binding mechanisms - Andrew AB Blyth
- Investigating the molecular and functional impact of a novel DLG2/PSD-93 mutation in neurodevelopmental disorders - Eddy Yang
- Understanding differences in mutation tolerance between populations at the sequence and structural level - Elston N Dsouza
- Purification and structural determination of amylin receptor complexes with heterotrimeric Gs protein. - Jianjun Cao
- Structure and functional studies of alkylhydroperoxidase D from Streptococcus pneumoniae reveal an unusual three-cysteine active site architecture - Yanxiang Meng
- Building a puzzle in the dark: developing small molecule inhibitors for heparanase - Junming He
- Structural studies of granulocyte colony stimulating factor and its receptor - Kaiseal Sarson-Lawrence
- High affinity TCRs from CD4+ T cells confer cytotoxic and HLA cross-restrictive potential - Christian CL Lobos
- Investigating the role of serglycin and proteoglycan glycosylation in Cytotoxic T lymphocyte function. - Alejandro A Torres
- The molecular chaperone β-casein prevents amorphous and fibrillar aggregation of α-lactalbumin by stabilisation of dynamic disorder - Henry M Sanders
- Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence - Paul R.F. Cordero
- Structural basis for a natural circular permutation in proteins - Samuel G Nonis
- BastionX: Systematic and accurate prediction of secreted substrates in Gram-negative bacteria within a distributed framework - Jiawei Wang
- Structural characterisation of molybdate acquisition by ModA in Pseudomonas aeruginosa - Dalton H. Y. Ngu
- Protein structural evolution tunes phycobiliprotein photon capture and excitation energy transport - Harry W Rathbone
- The structure and function of novel Coxiella burnetii effector proteins - Cameron C Oppy
- The Commander Protein Complex and its Role in Intracellular Membrane Trafficking - Michael D Healy
- A model for the activation of atp grasp enzymes by monovalent cations - Jordan L Pederick
- The CopC protein from Pseudomonas fluorescens SBW25 revisited - Johan Ørskov Ipsen
- Understanding the role of the Scribble PDZ domains in cell polarity regulation - Ivan How
- Characterising a novel Type VI DNase effector and immunity protein pair from Acinetobacter baumannii - Brooke K Hayes
Dinner (own arrangements)
6:00PM - 7:45PM
Tuesday, 11th February
Session 10 - Robin Anders Young Investigators Award session
7:45PM - 9:00PM
Tuesday, 11th February
Auditorium
Chairs: Megan Maher & Jessica Bridgford
Sponsored by:
- Using cryo-EM to study conformational and compositional states of the native ABC holotoxin YenTc - Sarah J Piper
- Structural determination of the docosahexaenoic acid transporter MFSD2A - Rosemary J Cater
- The structure of the interleukin-11 signalling complex guides therapeutic design - Riley D Metcalfe
- Physiological and structural basis of cofactor F420 biosynthesis in mycobacteria - Rhys Grinter
Poster session D - including Happy hour & Trade display
9:00PM - 10:00PM
Tuesday, 11th February
- Identification of novel periplasmic chaperones involved in the biogenesis of the bacterial Translocase Assembly Machinery – TAM - Chaille T Webb
- The periplasm under stress - Rebecca Bamert
- Circling back to 1955: biosynthesis of evolidine, the first plant cyclopeptide discovered - Joshua S Mylne
- The mechanism of action of a bacterial DNA replication inhibitor - Amy E McGrath
- Cell type dependent roles of p120ctn in regulating Wnt signaling pathway and epithelial-to-mesenchymal transition - H Pamali M Fonseka
- The MX3 beamline at the Australian Synchrotron. Conceptual design and capabilities. - Tom T Caradoc-Davies
- The crystal structure of the light harvesting protein PE566 from the cryptophyte alga Cryptomonas pyrenoidifera - Katharine A Michie
- Structural studies of interactions between PRL phosphatases and CNNM magnesium transporters - Guennadi Kozlov
- Binding free energy, MD simulation and docking calculations of HCV protease interactions with sulfonamidobenzamide inhibitors - Michael Johnson
- Matrix metalloproteinase down regulation of the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase contrasts enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase - Chris M Overall
- Mechanisms of RNA-targeting by CRISPR-Cas13 - Gavin J Knott
- Rapid Elaboration of Fragments into Leads (REFiL). A systematic approach to fragment elaboration. - Menachem J Gunzburg
- Lipid order and charge protect killer T cells from accidental death - Jesse A Rudd-Schmidt
- Spectroscopy data collection and analysis for determining protein secondary structure: a neural network approach to circular dichroism and infra red spectroscopy of peptides and proteins in solution, membranes and assemblies - Alison Rodger
- How do bacteria fold αβ-Barrel proteins? - Christopher J Stubenrauch
- Drug Discovery at the Human Calcium Sensing Receptor - Andrew N Keller
- Unravelling the features of HIV-specific CD4+ T cells to improve HIV clearance - Dimitra SM Chatzileontiadou
- Structural basis for the recognition of nectin-like protein-5 by the human activating immune receptor, DNAM-1 - Gabrielle M Watson
- The evolution of HLA-A2-M158-66 epitope-specific CD8+ T cell repertoires during aging - Christopher Szeto
- Elucidating the role of aspartate decarboxylase in the mechanism of action of the anti-tuberculosis drug pyrazinamide - Christina Spry
- BioSAXS: a beamline dedicated to protein solution scattering at the Australian Synchrotron - Christina Kamma-Lorger
- Mapping the Structure Activity Relationship of oxazolidinone antibiotics with the Staphylococcus ribosome - Matthew Belousoff
- Working toward better understanding of the gating mechanism of the hERG potassium channel - Carus Lau
- Temperate bacteriophage 186 — the mature virion and the lysis/lysogeny switch - FIONA WHELAN
- Quantifying proteome remodelling during cellular stress - Dezerae Cox