Aspergillus fumigatus is an opportunistic fungal pathogen and is the main etiological agent of invasive aspergillosis. In immunocompromised patients, it has an unacceptably high mortality rate of up to 95%. A structural genomics pipeline has been set up to facilitate the determination and analysis of structures of proteins from A. fumigatus. Since its inception in 2014, we have contributed 15% of all A. fumigatus structures deposited in the Protein Data Bank. Three recent structures solved from this project are nucleoside diphosphate kinase, an essential enzyme involved in DNA synthesis; enolase, an enzyme that catalyses the penultimate step of glycolysis; and guanosine monophosphate synthetase, an enzyme essential for virulence in A. fumigatus. This provides a solid foundation for identifying novel targets for structure-based drug design and lead optimisation to treat invasive aspergillosis infections.