Poster Presentation The 45th Lorne Conference on Protein Structure and Function 2020

Characterization of Reversible Peptide Hydrogels (#207)

Fabian Dolamore 1 2 , Julian Menges 1 2 , Renwick Dobson 1 2
  1. University of Canterbury, Christchurch, CANTERBURY, New Zealand
  2. Biomolecular Interaction Centre, University of Canterbury, Christchurch, Canterbury, New Zealand

Hydrogels are viscoelastic fluids comprising interlinked organic molecules and are valued for their softness, flexibility and biocompatibility. We report on a small peptide, EL-5F, that rapidly and reversibly self-assembles into beta-sheet amyloid fibrils at low pH, corresponding to protonation of its acidic residues – resulting in a weak hydrogel. Furthermore, this gelation behaviour is enhanced by PEGylation of the peptide at the N-terminus as a result of increased peptide solubility. Before these intriguing hydrogels can be practically implemented, a comprehensive characterization of their response to a variety of stimulii is required. We present a systematic study of the influence of several variables, namely: pH, concentration, ionic strength and PEG length on the structure of these peptide hydrogels at the molecular and macroscopic level.