Monday, 10th February The 45th Lorne Conference on Protein Structure and Function 2020
Registration
8:00AM - 1:30PM
Monday, 10th February
Session 3 - Global Processes
8:30AM - 10:30AM
Monday, 10th February
Auditorium
Chairs: John Bruning & Craig Morton
- On the Origin of Folded Proteins - Andrei Lupas
- Structural and functional insights into human condensin I and II - Erin Cutts
- The crystal structure of the epigenetic regulator SMCHD1 hinge domain reveal its dimerisation, nucleic-acid binding and chromatin interactions - Richard W Birkinshaw
- Emerging concepts in protein interactions: from enzymes to organelles - Monika Fuxreiter
Morning Tea
10:30AM - 11:00AM
Monday, 10th February
Session 4 - Moving Small Molecules
11:00AM - 1:00PM
Monday, 10th February
Auditorium
Chair: Alice Vrielink
- The structural basis for allosteric regulation of RyR1 gating - Oliver Clarke
- K+ ion pass through the narrow ‘gate’ of a potassium channel partially dehydrated - Katrina Black
- Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer. - Jo Parker
- Bioactive lipids inhibit the glycine transporter, GlyT2, by penetrating transmembrane helices at an allosteric site - Shannon N Mostyn
- Functionally important residues identified in a putative drug-binding pocket of the MtrD efflux protein from Neisseria gonorrhoeae - Melissa H Brown
Lunch
1:00PM - 2:00PM
Monday, 10th February
Future Leaders Lunch
1:00PM - 2:00PM
Monday, 10th February
Horizons Room
Synchrotron Users Group Meeting
1:15PM - 2:15PM
Monday, 10th February
Auditorium
Free Time
2:00PM - 3:00PM
Monday, 10th February
Registration re-opens
2:30PM - 5:30PM
Monday, 10th February
Thermo Fisher Trade Workshop
3:00PM - 4:00PM
Monday, 10th February
Auditorium
Sponsored by:
Poster Session A - including refreshments
4:00PM - 6:00PM
Monday, 10th February
- The Coxiella burnetii effector protein MceB targets the mitochondria during infection - Laura Fielden
- The crystal structure of Smchd1's hinge domain reveals its dimerization and nucleic-acid binding mode - Alexandra D Gurzau
- Engineering a FRET-based biosensor for visualising hippocampal D-serine - Vanessa Vongsouthi
- Metal-dependent dynamic equilibrium: A mechanism for regulation of the Plasmodium M17 aminopeptidases? - Tess R Malcolm
- Two-component pore formation by the CDCL proteins ALY short and ALY long from Elizabethkingia anophelis - Bronte A Johnstone
- Structural insights to understand and determine novel drug resistance in tuberculosis - Malancha Karmakar
- SUSPECT-RIF A structure-based predictive tool for identifying rifampicin resistance - Stephanie Portelli
- Orthogonal evidence for Olfactory Receptors can be used for agonist prediction - Amara Jabeen
- Investigating a common structural element in T- and B-cell antigen receptor transmembrane assembly - Samyuktha Ramesh
- Using a mammalian cell lentivirus directed evolution platform to increase cell surface expression and stability of the oxytocin receptor. - Lisa M Williams
- Purification and structural characterization of TACAN, a novel ion channel implicated in pain sensing - Nazanin Mohebali
- Structural characterisation of a mutation in p97 that induces multisystem proteionopathy - Sepideh Valimehr
- Investigating the molecular evolution of imipenem-resistance in clinical isolates of Klebsiella - Natalia C. Rosas Bastidas
- Structural studies of VDAC2 in BAX/BAK-mediated apoptosis - Zheng Yuan
- Development of small molecule inhibitors of pathogenic and functional amyloid associated with human and plant diseases. - Sarah R Ball
- Investigating the role of the Hsp40/Hsp70 chaperone system in regulating the intracellular protein aggregation of firefly luciferase - Shannon McMahon
- Computational design of a stabilized version of human heparanase for E.coli expression - Cassidy Whitefield
- Insights into the translocation of the class A beta-lactamase BKC-1 - Manasa Bharathwaj
- Time-resolved structural studies of Sensory Rhodopsin II - Giorgia Ortolani
- Structural biology of the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax protein subversion on the Scribble cell polarity module. - Airah Javorsky
- Identifying the active site of CdSpoVD a sporulation specific penicillin binding protein from Clostridioides difficile - Clara E Bate
- Structural and allosteric studies of the M4 and M5 muscarinic acetylcholine receptors - Liudi Zhang
- Structural insight into TNP16L mediated apoptosis inhibition by Tana-pox virus - Chathura D Suraweera
- The Gram-negative bacterial periplasm; Architecture significance - Eric JL Mandela
- Biophysical insight into DNA recognition and repression by a family of ancestrally reconstructed LacI/GalR transcriptional regulators - Matthew Spence
- Optimising production of bioorthogonal cofactor F420 in non-native host E. coli. - James Antoney
- Structural analysis of phosphorylation-associated interactions of human MCC to Scribble PDZ domains - Bryce Stewart
- Structural Landscapes of Protein-Protein Interaction Interfaces - Carlos HM Rodrigues
- The development of a protein folding-sensor to study molecular chaperones at the single-molecule level - Nicholas Marzano
- Measuring intolerance to missense variation within protein tertiary structures - Michael Silk
- Asymmetric Reduction of α,β-unsaturated compounds using FDORs MEMEG_2027 and MEMEG_2850 - Suk Woo Kang
- A novel function for human Tim8 proteins in the biogenesis of mitochondrial Complex IV - Alex Anderson
- Towards the characterization of the relaxin receptor, RXFP1 - Jonathan Siah
- Guiding rational antibody engineering using graph-based signatures - YooChan Myung
- MR1 restricted Vδ3+ T cells adopt an unconventional binding mode - Michael T. Rice
- Characterisation of the extracellular chaperone activities of pregnancy zone protein (PZP) and plasminogen activator inhibitor type-2 (PAI-2) - Jordan Cater
- The immune adaptor TRIF that signals for programmed cell death forms hybrid amyloids with other necroptosis-associated proteins - Max O. D. G. Baker
- The role of functional amyloid in the human necroptosis cascade and its modulation by herpesviruses - Nirukshan Shanmugam
- Identification of mechanisms of ribosomal stalling induced by arginine-rich dipolypeptide repeats - Viacheslav Kriachkov
- Designer Enzymes and Synthetic Cofactors for Biocatalysis - Jake W. Saunders
- A Novel Chemokine-Binding Tick Evasin: EVA-AMA-01 - Shankar Raj Devkota
- Functional insight into chemokine-neutralising activity of novel tick Evasins - Pramod Aryal
- Characterising G protein coupling at the M2 mAChR through the use of nanodiscs - Wessel A. C. Burger
- In-host evolution of carbapenem resistance in Klebsiella pneumoniae - Tao Chen
- Cryo-EM studies of the AAA+ ATPase p97 in Plasmodium falciparum - George Kobakhidze
- Two novel orthologue MLKL pseudokinase structures identify structural features important for necroptosis - Katherine Anne A Davies
Dinner (own arrangements)
6:00PM - 8:00PM
Monday, 10th February
Poster session B - including happy hour & trade display
8:00PM - 9:00PM
Monday, 10th February
- Tandem RNA binding sites induce self-association of stress granule marker protein TIA-1. - Fionna Loughlin
- Small-angle X-ray scattering as a quantitative screening tool - Po-chia Chen
- Characterisation of MlaC from Acinetobacter baumannii - Matthew Johnson
- Investigation of the Mitochondrial Translocase of the Outer Membrane (TOM) of Drosophila melanogaster - Agalya Periasamy
- A Dimeric, Luminescent Biosensor for Rapid and Sensitive Detection of DNA In Live Cells - David Segal
- Assessing Biosimilarity by HDX-MS - Heather Patsiouras
- Structural characterisation of the cholesterol sensitive CCK1 receptor - Jesse I. Mobbs
- Characterization of Reversible Peptide Hydrogels - Fabian Dolamore
- High-resolution cryo-EM structures of RNA polymerase complexes provide mechanistic insights into transcription in Firmicutes - Gökhan Tolun
- Tandem Domain Evasins: Inhibitors of Chemokine-mediated Inflammation - Ram Prasad Bhusal
- 2019 cryo-EM model metrics challenge - Andriy Kryshtafovych
- Differentiating between inhibitor binding modes of cytochrome P450 metalloenzymes - Stephen G Bell
- Structural insights into human mitochondrial PNPase in RNA import - Bagher Golzarroshan
- Bivalent recognition of Cyclin-dependent Kinase 2- associated Protein 1 by CHD4 and P66β is required for its interaction with the NuRD complex - Hakimeh Moghaddas Sani
- Structural characterisation of mitochondrial complex IV assembly factors - Shadi Maghool
- Structural and functional characterization of the C-terminal domains of CzcD proteins - Saumya R Udagedara
- Kinetic characterization of allosteric modulation at different conformational states of a GPCR: a novel application of SPR - Jianrong Xu
- Structural insight into Bcl-2 mediated cell death in Hydra vulgaris - Suresh Banjara
- Insight into the mechanisms of substrate specificity in algal desaturases - Adam M Damry
- Biochemical characterisation of the RBR E3 ligase RNF216/TRIAD3 - Tom Cotton
- Switch it off to switch it on - Activating Hedgehog signalling by inhibiting Patched function - Christiane Kowatsch
- Nanoscale study of perforin pore formation and lipid specificity - Adrian W Hodel
- Sending enzyme activity PACking: A structural approach to engineering a commonly used selectable marker - Alessandro T Caputo
- Insights into molecular mechanisms of self-assembly of amyloids in presence and absence of metals - Yifat Miller
- Mechanism of site-specific deubiquitination of FANCD2 by USP1-UAF1 - Helen Walden
- Novel Drivers and Modifiers of MPL-dependent Oncogenic Transformation Identified by Deep Mutational Scanning - Jessica L Bridgford
- Disparate docking underpins diverse NKT TCR mediated anti-microbial immunity - Srinivasan sundararaj
- Intrinsically disordered sequences and electrostatic interactions are essential for caveola formation by Cavin1 - Brett Collins